Musculoskeletal disorder after Cyclosporine (Atopica) in dogs

40 reports to the FDA describe musculoskeletal disorder in dogs given Cyclosporine. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

40Reports

55%Marked serious

20%Recovered

13%Died or euthanised

48 daysTypical onset

How soon it started

Same day

2 14%

1–2 days

0 0.0%

3–7 days

1 7.1%

1–4 weeks

1 7.1%

Over a month

10 71%

How the animals did

Recovered

7 18%

Recovered with lasting effects

1 2.5%

Still unwell when reported

11 28%

Died

2 5.0%

Euthanised

3 7.5%

Not known

16 40%

Problems reported at the same time

11 28%

10 25%

7 18%

6 15%

5 13%

5 13%

5 13%

5 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause musculoskeletal disorder in dogs?: 40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 48 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Musculoskeletal disorder with similar medicines

Musculoskeletal disorder after Oclacitinib (Apoquel) 176 reports · 0.6% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with musculoskeletal disorder