Disorientation after Cyclosporine (Atopica) in dogs

The FDA has received 133 reports of disorientation in dogs after Cyclosporine. That is 0.9% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

133Reports

30%Marked serious

16%Recovered

14%Died or euthanised

14 daysTypical onset

How soon it started

Same day

8 21%

1–2 days

6 15%

3–7 days

2 5.1%

1–4 weeks

12 31%

Over a month

11 28%

How the animals did

Recovered

20 15%

Recovered with lasting effects

1 0.8%

Still unwell when reported

11 8.3%

Died

10 7.5%

Euthanised

8 6.0%

Not known

83 62%

Problems reported at the same time

Lethargy

46 35%

Vomiting

36 27%

Loss of appetite

28 21%

Restlessness or agitation

23 17%

22 17%

21 16%

19 14%

18 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause disorientation in dogs?: 133 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Disorientation with similar medicines

Disorientation after Oclacitinib (Apoquel) 311 reports · 1.1% of its reports
Disorientation after Ilunocitinib (Zenrelia) 21 reports · 1.0% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with disorientation