Liver problems after Capromorelin (Entyce) in dogs

The FDA has received 207 reports of liver problems in dogs after Capromorelin. That is 14% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

207Reports

85%Marked serious

9.2%Recovered

49%Died or euthanised

9 daysTypical onset

How soon it started

Same day

27 16%

1–2 days

27 16%

3–7 days

28 17%

1–4 weeks

33 20%

Over a month

51 31%

How the animals did

Recovered

18 8.7%

Recovered with lasting effects

1 0.5%

Still unwell when reported

54 26%

Died

31 15%

Euthanised

71 34%

Not known

32 15%

Problems reported at the same time

130 63%

107 52%

102 49%

99 48%

84 41%

61 29%

52 25%

42 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Capromorelin stimulates appetite.

Products with this ingredient include Entyce, Elura. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Capromorelin cause liver problems in dogs?: 207 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 9 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

Liver problems after Maropitant (Cerenia) 2,056 reports · 17% of its reports
Liver problems after Mirtazapine (Mirataz) 86 reports · 30% of its reports

All reported side effects of Capromorelin in dogs · Medicines most reported with liver problems