Overdose after Buprenorphine in dogs

31 reports to the FDA describe overdose in dogs given Buprenorphine. That is 2.0% of all reports for this medicine, compared with 1.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

31Reports

84%Marked serious

29%Recovered

9.7%Died or euthanised

Same dayTypical onset

How soon it started

Same day

17 57%

1–2 days

2 6.7%

3–7 days

4 13%

1–4 weeks

6 20%

Over a month

1 3.3%

How the animals did

Recovered

9 29%

Still unwell when reported

8 26%

Euthanised

3 9.7%

Not known

11 35%

Problems reported at the same time

Liver problems

12 39%

Injection site reaction

10 32%

Loss of appetite

8 26%

Swelling

7 23%

Vocalising

7 23%

Didn't work as expected

7 23%

Weakness

7 23%

Lethargy

5 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Buprenorphine pain relief (an opioid).

Questions owners ask

Can Buprenorphine cause overdose in dogs?: 31 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Overdose with similar medicines

Overdose after Dexmedetomidine (Dexdomitor) 179 reports · 3.3% of its reports

All reported side effects of Buprenorphine in dogs · Medicines most reported with overdose