Bradycardia after Buprenorphine in dogs

71 reports to the FDA describe bradycardia in dogs given Buprenorphine. That is 4.5% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

71Reports

73%Marked serious

54%Recovered

20%Died or euthanised

Same dayTypical onset

How soon it started

Same day

49 79%

1–2 days

4 6.5%

3–7 days

4 6.5%

1–4 weeks

3 4.8%

Over a month

2 3.2%

How the animals did

Recovered

38 54%

Still unwell when reported

9 13%

Died

10 14%

Euthanised

4 5.6%

Not known

10 14%

Problems reported at the same time

Death

14 20%

Didn't work as expected

12 17%

10 14%

10 14%

10 14%

9 13%

9 13%

8 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Buprenorphine pain relief (an opioid).

Questions owners ask

Can Buprenorphine cause bradycardia in dogs?: 71 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Bradycardia with similar medicines

Bradycardia after Dexmedetomidine (Dexdomitor) 597 reports · 11% of its reports

All reported side effects of Buprenorphine in dogs · Medicines most reported with bradycardia