Hyperkalaemia after Bedinvetmab (Librela) in dogs

The FDA has received 83 reports of hyperkalaemia in dogs after Bedinvetmab. That is 0.4% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

83Reports

80%Marked serious

1.2%Recovered

40%Died or euthanised

31 daysTypical onset

How soon it started

Same day

11 16%

1–2 days

8 12%

3–7 days

3 4.5%

1–4 weeks

11 16%

Over a month

34 51%

How the animals did

Recovered

1 1.2%

Still unwell when reported

42 51%

Died

9 11%

Euthanised

24 29%

Not known

7 8.4%

Problems reported at the same time

54 65%

39 47%

37 45%

33 40%

25 30%

22 27%

21 25%

Elevated symmetrical dimethylarginine (sdma)

20 24%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Bedinvetmab reduces osteoarthritis pain in dogs (monthly injection).

Products with this ingredient include Librela. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Bedinvetmab cause hyperkalaemia in dogs?: 83 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperkalaemia with similar medicines

Hyperkalaemia after Lokivetmab (Cytopoint) 27 reports · 0.4% of its reports

All reported side effects of Bedinvetmab in dogs · Medicines most reported with hyperkalaemia