Hypercalcaemia after Bedinvetmab (Librela) in dogs

The FDA has received 109 reports of hypercalcaemia in dogs after Bedinvetmab. That is 0.6% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

109Reports

69%Marked serious

0.9%Recovered

37%Died or euthanised

19 daysTypical onset

How soon it started

Same day

13 15%

1–2 days

8 9.4%

3–7 days

12 14%

1–4 weeks

21 25%

Over a month

31 36%

How the animals did

Recovered

1 0.9%

Still unwell when reported

60 55%

Died

5 4.6%

Euthanised

35 32%

Not known

8 7.3%

Problems reported at the same time

65 60%

54 50%

49 45%

39 36%

33 30%

31 28%

25 23%

25 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Bedinvetmab reduces osteoarthritis pain in dogs (monthly injection).

Products with this ingredient include Librela. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Bedinvetmab cause hypercalcaemia in dogs?: 109 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 19 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypercalcaemia with similar medicines

Hypercalcaemia after Lokivetmab (Cytopoint) 31 reports · 0.5% of its reports

All reported side effects of Bedinvetmab in dogs · Medicines most reported with hypercalcaemia