Elevated creatine-kinase (ck) after Bedinvetmab (Librela) in dogs

52 reports to the FDA describe elevated creatine-kinase (ck) in dogs given Bedinvetmab. That is 0.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

52Reports

81%Marked serious

7.7%Recovered

23%Died or euthanised

31 daysTypical onset

How soon it started

Same day

1 2.1%

1–2 days

4 8.5%

3–7 days

8 17%

1–4 weeks

9 19%

Over a month

25 53%

How the animals did

Recovered

3 5.8%

Recovered with lasting effects

1 1.9%

Still unwell when reported

33 63%

Died

1 1.9%

Euthanised

11 21%

Not known

3 5.8%

Problems reported at the same time

32 62%

18 35%

16 31%

13 25%

13 25%

12 23%

Decreased urine concentration

12 23%

Death

12 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Bedinvetmab reduces osteoarthritis pain in dogs (monthly injection).

Products with this ingredient include Librela. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Bedinvetmab cause elevated creatine-kinase (ck) in dogs?: 52 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Bedinvetmab in dogs · Medicines most reported with elevated creatine-kinase (ck)