Proteinuria after Amoxicillin in dogs

The FDA has received 48 reports of proteinuria in dogs after Amoxicillin. That is 3.6% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

48Reports

71%Marked serious

2.1%Recovered

40%Died or euthanised

40 daysTypical onset

How soon it started

Same day

4 12%

1–2 days

2 5.9%

3–7 days

1 2.9%

1–4 weeks

8 24%

Over a month

19 56%

How the animals did

Recovered

1 2.1%

Still unwell when reported

22 46%

Died

7 15%

Euthanised

12 25%

Not known

6 13%

Problems reported at the same time

31 65%

25 52%

24 50%

19 40%

19 40%

17 35%

14 29%

Abnormal ultrasound finding

13 27%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Amoxicillin treats bacterial infections.

Questions owners ask

Can Amoxicillin cause proteinuria in dogs?: 48 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 40 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proteinuria with similar medicines

Proteinuria after Amoxicillin + Clavulanate (Clavamox) 138 reports · 2.6% of its reports
Proteinuria after Doxycycline 74 reports · 1.8% of its reports
Proteinuria after Cefovecin (Convenia) 50 reports · 1.3% of its reports
Proteinuria after Enrofloxacin (Baytril) 68 reports · 1.8% of its reports
Proteinuria after Metronidazole 72 reports · 2.3% of its reports

All reported side effects of Amoxicillin in dogs · Medicines most reported with proteinuria