Elevated symmetrical dimethylarginine (sdma) after Amoxicillin in dogs

22 reports to the FDA describe elevated symmetrical dimethylarginine (sdma) in dogs given Amoxicillin. That is 1.6% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

22Reports
82%Marked serious
0.0%Recovered
36%Died or euthanised
26 daysTypical onset
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How soon it started

Same day
2 12%
1–2 days
3 18%
3–7 days
1 5.9%
1–4 weeks
3 18%
Over a month
8 47%

How the animals did

Still unwell when reported
10 45%
Died
1 4.5%
Euthanised
7 32%
Not known
4 18%

Problems reported at the same time

Kidney problems
14 64%
Liver problems
13 59%
Loss of appetite
11 50%
Hypoalbuminaemia
8 36%
Lethargy
8 36%
Death
8 36%
Monocytosis
8 36%
Vomiting
7 32%

Age of the animals

Under 1 year
3
1–3 years
1
4–7 years
5
8–11 years
5
12+ years
8

About this medicine

Amoxicillin treats bacterial infections.

Questions owners ask

Can Amoxicillin cause elevated symmetrical dimethylarginine (sdma) in dogs?
22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 26 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated symmetrical dimethylarginine (sdma) with similar medicines

All reported side effects of Amoxicillin in dogs · Medicines most reported with elevated symmetrical dimethylarginine (sdma)