Elevated globulins after Amoxicillin + Clavulanate (Clavamox) in dogs

The FDA has received 67 reports of elevated globulins in dogs after Amoxicillin + Clavulanate. That is 1.2% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

67Reports
75%Marked serious
1.5%Recovered
27%Died or euthanised
20 daysTypical onset
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How soon it started

Same day
2 4.1%
1–2 days
4 8.2%
3–7 days
11 22%
1–4 weeks
17 35%
Over a month
15 31%

How the animals did

Recovered
1 1.5%
Still unwell when reported
37 55%
Died
6 9.0%
Euthanised
12 18%
Not known
11 16%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
6
4–7 years
17
8–11 years
27
12+ years
12

About this medicine

Amoxicillin treats bacterial infections.

Products with this combination include Clavamox. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Amoxicillin + Clavulanate cause elevated globulins in dogs?
67 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 20 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated globulins with similar medicines

All reported side effects of Amoxicillin + Clavulanate in dogs · Medicines most reported with elevated globulins