Eye disorder (for photophobia see 'neurological') after Sarolaner + Selamectin (Revolution Plus) in cats

21 reports to the FDA describe eye disorder (for photophobia see 'neurological') in cats given Sarolaner + Selamectin. That is 0.3% of all reports for this medicine, compared with 0.3% across reports for all cat medicines.

21Reports
29%Marked serious
24%Recovered
4.8%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
15 71%
1–2 days
5 24%
3–7 days
1 4.8%
1–4 weeks
0 0.0%
Over a month
0 0.0%

How the animals did

Recovered
5 24%
Still unwell when reported
3 14%
Euthanised
1 4.8%
Not known
12 57%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
6
4–7 years
4
8–11 years
5
12+ years
3

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly. Selamectin prevents heartworm and treats fleas, ear mites and some worms (spot-on).

Products with this combination include Revolution Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner + Selamectin cause eye disorder (for photophobia see 'neurological') in cats?
21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Sarolaner + Selamectin in cats · Medicines most reported with eye disorder (for photophobia see 'neurological')