Drooling after Imidacloprid + Pyriproxyfen in cats

40 reports to the FDA describe drooling in cats given Imidacloprid + Pyriproxyfen. That is 6.1% of all reports for this medicine, compared with 5.6% across reports for all cat medicines.

40Reports
40%Marked serious
50%Recovered
2.5%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
16 48%
1–2 days
4 12%
3–7 days
2 6.1%
1–4 weeks
9 27%
Over a month
2 6.1%

How the animals did

Recovered
20 50%
Still unwell when reported
3 7.5%
Euthanised
1 2.5%
Not known
16 40%

Problems reported at the same time

12 30%
Tremors
5 13%
4 10%
Respiratory sound
4 10%

Age of the animals

Under 1 year
13
1–3 years
13
4–7 years
8
8–11 years
2
12+ years
3

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Pyriproxyfen cause drooling in cats?
40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

All reported side effects of Imidacloprid + Pyriproxyfen in cats · Medicines most reported with drooling