Drooling after Spinosad (Comfortis) in cats

157 reports to the FDA describe drooling in cats given Spinosad. That is 1.4% of all reports for this medicine, compared with 5.6% across reports for all cat medicines, so it is reported less often than average with this medicine.

157Reports
19%Marked serious
55%Recovered
5.1%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
88 62%
1–2 days
11 7.7%
3–7 days
10 7.0%
1–4 weeks
9 6.3%
Over a month
24 17%

How the animals did

Recovered
77 49%
Recovered with lasting effects
9 5.7%
Still unwell when reported
11 7.0%
Died
7 4.5%
Euthanised
1 0.6%
Not known
52 33%

Problems reported at the same time

77 49%
29 18%
14 8.9%
14 8.9%
13 8.3%
12 7.6%

Age of the animals

Under 1 year
18
1–3 years
51
4–7 years
37
8–11 years
23
12+ years
16

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause drooling in cats?
157 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

All reported side effects of Spinosad in cats · Medicines most reported with drooling