Loss of appetite after Spinosad (Comfortis) in cats

632 reports to the FDA describe loss of appetite in cats given Spinosad. That is 5.5% of all reports for this medicine, compared with 14% across reports for all cat medicines, so it is reported less often than average with this medicine.

632Reports
29%Marked serious
51%Recovered
12%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
305 56%
1–2 days
98 18%
3–7 days
33 6.1%
1–4 weeks
29 5.3%
Over a month
79 15%

How the animals did

Recovered
240 38%
Recovered with lasting effects
85 13%
Still unwell when reported
82 13%
Died
43 6.8%
Euthanised
33 5.2%
Not known
149 24%

Problems reported at the same time

Age of the animals

Under 1 year
66
1–3 years
131
4–7 years
136
8–11 years
121
12+ years
136

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause loss of appetite in cats?
632 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Spinosad in cats · Medicines most reported with loss of appetite