Itching after Spinosad (Comfortis) in cats

The FDA has received 439 reports of itching in cats after Spinosad. That is 3.8% of all reports for this medicine, compared with 8.9% across reports for all cat medicines, so it is reported less often than average with this medicine.

439Reports
16%Marked serious
44%Recovered
3.2%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
207 54%
1–2 days
17 4.4%
3–7 days
31 8.1%
1–4 weeks
45 12%
Over a month
85 22%

How the animals did

Recovered
115 26%
Recovered with lasting effects
76 17%
Still unwell when reported
57 13%
Died
7 1.6%
Euthanised
7 1.6%
Not known
177 40%

Problems reported at the same time

Age of the animals

Under 1 year
50
1–3 years
105
4–7 years
96
8–11 years
70
12+ years
62

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause itching in cats?
439 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Itching with similar medicines

All reported side effects of Spinosad in cats · Medicines most reported with itching