Restlessness or agitation after Spinosad (Comfortis) in cats

229 reports to the FDA describe restlessness or agitation in cats given Spinosad. That is 2.0% of all reports for this medicine, compared with 4.9% across reports for all cat medicines, so it is reported less often than average with this medicine.

229Reports

19%Marked serious

52%Recovered

3.1%Died or euthanised

Same dayTypical onset

How soon it started

Same day

156 80%

1–2 days

6 3.1%

3–7 days

8 4.1%

1–4 weeks

6 3.1%

Over a month

18 9.3%

How the animals did

Recovered

101 44%

Recovered with lasting effects

17 7.4%

Still unwell when reported

20 8.7%

Died

6 2.6%

Euthanised

1 0.4%

Not known

84 37%

Problems reported at the same time

85 37%

58 25%

45 20%

41 18%

40 17%

29 13%

17 7.4%

16 7.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause restlessness or agitation in cats?: 229 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Nitenpyram (Capstar) 2,987 reports · 34% of its reports
Restlessness or agitation after Imidacloprid + Moxidectin (Advantage Multi) 682 reports · 8.4% of its reports
Restlessness or agitation after Lufenuron 20 reports · 1.8% of its reports
Restlessness or agitation after Flumethrin + Imidacloprid (Seresto) 27 reports · 4.0% of its reports
Restlessness or agitation after Imidacloprid + Pyriproxyfen 46 reports · 7.0% of its reports
Restlessness or agitation after Fipronil 59 reports · 12% of its reports
Restlessness or agitation after Fipronil + S-methoprene (Frontline Plus) 33 reports · 9.0% of its reports
Restlessness or agitation after Imidacloprid 28 reports · 11% of its reports

All reported side effects of Spinosad in cats · Medicines most reported with restlessness or agitation