Itching after Imidacloprid + Pyriproxyfen in cats

222 reports to the FDA describe itching in cats given Imidacloprid + Pyriproxyfen. That is 34% of all reports for this medicine, compared with 8.9% across reports for all cat medicines, so it is reported unusually often with this medicine.

222Reports
41%Marked serious
16%Recovered
0.9%Died or euthanised
21 daysTypical onset
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How soon it started

Same day
11 9.5%
1–2 days
5 4.3%
3–7 days
8 6.9%
1–4 weeks
49 42%
Over a month
43 37%

How the animals did

Recovered
35 16%
Still unwell when reported
17 7.7%
Died
1 0.5%
Euthanised
1 0.5%
Not known
168 76%

Problems reported at the same time

Age of the animals

Under 1 year
13
1–3 years
50
4–7 years
45
8–11 years
38
12+ years
41

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Pyriproxyfen cause itching in cats?
222 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 21 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Itching with similar medicines

All reported side effects of Imidacloprid + Pyriproxyfen in cats · Medicines most reported with itching