Didn't work as expected after Imidacloprid + Pyriproxyfen in cats

The FDA has received 24 reports of didn't work as expected in cats after Imidacloprid + Pyriproxyfen. That is 3.7% of all reports for this medicine, compared with 8.7% across reports for all cat medicines, so it is reported less often than average with this medicine.

24Reports

17%Marked serious

8.3%Recovered

4.2%Died or euthanised

–Typical onset

How the animals did

Recovered

2 8.3%

Still unwell when reported

13 54%

Died

1 4.2%

Not known

8 33%

Problems reported at the same time

18 75%

3 13%

2 8.3%

2 8.3%

Restlessness or agitation

2 8.3%

Hair loss

2 8.3%

Death

1 4.2%

Lethargy

1 4.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Pyriproxyfen cause didn't work as expected in cats?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Spinosad (Comfortis) 1,060 reports · 9.2% of its reports
Didn't work as expected after Nitenpyram (Capstar) 232 reports · 2.7% of its reports
Didn't work as expected after Imidacloprid + Moxidectin (Advantage Multi) 63 reports · 0.8% of its reports
Didn't work as expected after Fipronil 38 reports · 7.6% of its reports
Didn't work as expected after Fipronil + S-methoprene (Frontline Plus) 22 reports · 6.0% of its reports

All reported side effects of Imidacloprid + Pyriproxyfen in cats · Medicines most reported with didn't work as expected