Death after Fluralaner + Moxidectin (Bravecto Plus) in cats

124 reports to the FDA describe death in cats given Fluralaner + Moxidectin. That is 3.8% of all reports for this medicine, compared with 8.9% across reports for all cat medicines, so it is reported less often than average with this medicine.

124Reports
99%Marked serious
0.0%Recovered
100%Died or euthanised
4 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
23 26%
1–2 days
18 21%
3–7 days
7 8.0%
1–4 weeks
8 9.2%
Over a month
31 36%

How the animals did

Died
68 55%
Euthanised
56 45%

Problems reported at the same time

Age of the animals

Under 1 year
11
1–3 years
43
4–7 years
23
8–11 years
19
12+ years
22

About this medicine

Fluralaner kills fleas and ticks for up to 12 weeks (chewable or spot-on). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Bravecto Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Fluralaner + Moxidectin cause death in cats?
124 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

All reported side effects of Fluralaner + Moxidectin in cats · Medicines most reported with death