Neutrophilia after Trazodone in dogs

The FDA has received 76 reports of neutrophilia in dogs after Trazodone. That is 3.0% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

76Reports

87%Marked serious

7.9%Recovered

20%Died or euthanised

5 daysTypical onset

How soon it started

Same day

4 6.9%

1–2 days

11 19%

3–7 days

18 31%

1–4 weeks

8 14%

Over a month

17 29%

How the animals did

Recovered

5 6.6%

Recovered with lasting effects

1 1.3%

Still unwell when reported

39 51%

Died

3 3.9%

Euthanised

12 16%

Not known

16 21%

Problems reported at the same time

44 58%

39 51%

38 50%

34 45%

32 42%

31 41%

30 39%

25 33%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trazodone reduces anxiety and stress.

Questions owners ask

Can Trazodone cause neutrophilia in dogs?: 76 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutrophilia with similar medicines

Neutrophilia after Gabapentin 288 reports · 3.2% of its reports

All reported side effects of Trazodone in dogs · Medicines most reported with neutrophilia