Hyperproteinaemia after Trazodone in dogs

The FDA has received 27 reports of hyperproteinaemia in dogs after Trazodone. That is 1.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

27Reports

93%Marked serious

0.0%Recovered

33%Died or euthanised

27 daysTypical onset

How soon it started

Same day

2 9.5%

1–2 days

2 9.5%

3–7 days

4 19%

1–4 weeks

4 19%

Over a month

9 43%

How the animals did

Still unwell when reported

12 44%

Died

4 15%

Euthanised

5 19%

Not known

6 22%

Problems reported at the same time

18 67%

15 56%

15 56%

12 44%

12 44%

11 41%

9 33%

8 30%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Trazodone reduces anxiety and stress.

Questions owners ask

Can Trazodone cause hyperproteinaemia in dogs?: 27 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 27 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperproteinaemia with similar medicines

Hyperproteinaemia after Gabapentin 75 reports · 0.8% of its reports

All reported side effects of Trazodone in dogs · Medicines most reported with hyperproteinaemia