Lymphopenia after Tramadol in dogs

62 reports to the FDA describe lymphopenia in dogs given Tramadol. That is 1.6% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

62Reports
89%Marked serious
3.2%Recovered
39%Died or euthanised
17 daysTypical onset
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How soon it started

Same day
6 13%
1–2 days
6 13%
3–7 days
8 17%
1–4 weeks
9 19%
Over a month
19 40%

How the animals did

Recovered
1 1.6%
Recovered with lasting effects
1 1.6%
Still unwell when reported
23 37%
Died
9 15%
Euthanised
15 24%
Not known
13 21%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
20
8–11 years
27
12+ years
14

About this medicine

Type: medicine.

Questions owners ask

Can Tramadol cause lymphopenia in dogs?
62 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 17 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lymphopenia with similar medicines

All reported side effects of Tramadol in dogs · Medicines most reported with lymphopenia