Hypoproteinaemia after Tramadol in dogs

The FDA has received 63 reports of hypoproteinaemia in dogs after Tramadol. That is 1.7% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

63Reports
83%Marked serious
21%Recovered
40%Died or euthanised
13 daysTypical onset
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How soon it started

Same day
3 7.1%
1–2 days
5 12%
3–7 days
7 17%
1–4 weeks
12 29%
Over a month
15 36%

How the animals did

Recovered
12 19%
Recovered with lasting effects
1 1.6%
Still unwell when reported
20 32%
Died
6 9.5%
Euthanised
19 30%
Not known
5 7.9%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
6
4–7 years
25
8–11 years
22
12+ years
9

About this medicine

Type: medicine.

Questions owners ask

Can Tramadol cause hypoproteinaemia in dogs?
63 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 13 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoproteinaemia with similar medicines

All reported side effects of Tramadol in dogs · Medicines most reported with hypoproteinaemia