Hypoproteinaemia after Butorphanol in dogs

The FDA has received 51 reports of hypoproteinaemia in dogs after Butorphanol. That is 1.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

51Reports
78%Marked serious
18%Recovered
35%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
15 35%
1–2 days
5 12%
3–7 days
6 14%
1–4 weeks
9 21%
Over a month
8 19%

How the animals did

Recovered
9 18%
Still unwell when reported
9 18%
Died
6 12%
Euthanised
12 24%
Not known
15 29%

Problems reported at the same time

Age of the animals

Under 1 year
7
1–3 years
16
4–7 years
17
8–11 years
4
12+ years
7

About this medicine

Type: medicine.

Questions owners ask

Can Butorphanol cause hypoproteinaemia in dogs?
51 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoproteinaemia with similar medicines

All reported side effects of Butorphanol in dogs · Medicines most reported with hypoproteinaemia