Unresponsive after Spinosad (Comfortis) in dogs

166 reports to the FDA describe unresponsive in dogs given Spinosad. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

166Reports

37%Marked serious

15%Recovered

21%Died or euthanised

3 daysTypical onset

How soon it started

Same day

17 38%

1–2 days

5 11%

3–7 days

1 2.2%

1–4 weeks

4 8.9%

Over a month

18 40%

How the animals did

Recovered

17 10%

Recovered with lasting effects

8 4.8%

Still unwell when reported

7 4.2%

Died

20 12%

Euthanised

15 9.0%

Not known

99 60%

Problems reported at the same time

69 42%

43 26%

39 23%

37 22%

35 21%

31 19%

26 16%

Eye or vision problems

21 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause unresponsive in dogs?: 166 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unresponsive with similar medicines

Unresponsive after Lufenuron + Milbemycin Oxime (Sentinel) 64 reports · 0.2% of its reports
Unresponsive after Imidacloprid + Moxidectin (Advantage Multi) 32 reports · 0.2% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with unresponsive