Retching after Spinosad (Comfortis) in dogs

The FDA has received 149 reports of retching in dogs after Spinosad. That is 0.3% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

149Reports
23%Marked serious
44%Recovered
10%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
45 51%
1–2 days
15 17%
3–7 days
2 2.3%
1–4 weeks
3 3.4%
Over a month
23 26%

How the animals did

Recovered
53 36%
Recovered with lasting effects
13 8.7%
Still unwell when reported
10 6.7%
Died
14 9.4%
Euthanised
1 0.7%
Not known
58 39%

Problems reported at the same time

Age of the animals

Under 1 year
17
1–3 years
62
4–7 years
35
8–11 years
24
12+ years
7

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause retching in dogs?
149 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Retching with similar medicines

All reported side effects of Spinosad in dogs · Medicines most reported with retching