Polypnoea after Spinosad (Comfortis) in dogs

200 reports to the FDA describe polypnoea in dogs given Spinosad. That is 0.4% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

200Reports

0.0%Marked serious

0.0%Recovered

7.5%Died or euthanised

–Typical onset

How the animals did

Died

15 7.5%

Not known

185 93%

Problems reported at the same time

Lethargy

71 36%

Tremors

52 26%

Vomiting

40 20%

Restlessness or agitation

37 19%

34 17%

32 16%

23 12%

21 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause polypnoea in dogs?: 200 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Polypnoea with similar medicines

Polypnoea after Lufenuron + Milbemycin Oxime (Sentinel) 66 reports · 0.3% of its reports
Polypnoea after Imidacloprid + Moxidectin (Advantage Multi) 70 reports · 0.5% of its reports
Polypnoea after Nitenpyram (Capstar) 60 reports · 0.6% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with polypnoea