Pale mucous membrane after Spinosad (Comfortis) in dogs

155 reports to the FDA describe pale mucous membrane in dogs given Spinosad. That is 0.3% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

155Reports
55%Marked serious
32%Recovered
24%Died or euthanised
5 daysTypical onset
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How soon it started

Same day
27 32%
1–2 days
14 17%
3–7 days
5 6.0%
1–4 weeks
8 9.5%
Over a month
30 36%

How the animals did

Recovered
38 25%
Recovered with lasting effects
11 7.1%
Still unwell when reported
14 9.0%
Died
25 16%
Euthanised
12 7.7%
Not known
55 35%

Problems reported at the same time

Lethargy
89 57%
Vomiting
80 52%
Loss of appetite
59 38%
Blood problems
50 32%
Liver problems
42 27%
Death
37 24%
Collapse
27 17%
Breathing problems
26 17%

Age of the animals

Under 1 year
17
1–3 years
53
4–7 years
46
8–11 years
22
12+ years
16

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause pale mucous membrane in dogs?
155 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 5 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pale mucous membrane with similar medicines

All reported side effects of Spinosad in dogs · Medicines most reported with pale mucous membrane