Collapse after Spinosad (Comfortis) in dogs

190 reports to the FDA describe collapse in dogs given Spinosad. That is 0.3% of all reports for this medicine, compared with 0.9% across reports for all dog medicines, so it is reported less often than average with this medicine.

190Reports
52%Marked serious
28%Recovered
29%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
32 43%
1–2 days
8 11%
3–7 days
3 4.0%
1–4 weeks
6 8.0%
Over a month
26 35%

How the animals did

Recovered
34 18%
Recovered with lasting effects
20 11%
Still unwell when reported
8 4.2%
Died
39 21%
Euthanised
16 8.4%
Not known
73 38%

Problems reported at the same time

Age of the animals

Under 1 year
17
1–3 years
46
4–7 years
41
8–11 years
40
12+ years
40

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause collapse in dogs?
190 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Collapse with similar medicines

All reported side effects of Spinosad in dogs · Medicines most reported with collapse