Pain after Spinosad (Comfortis) in dogs

202 reports to the FDA describe pain in dogs given Spinosad. That is 0.4% of all reports for this medicine, compared with 0.7% across reports for all dog medicines, so it is reported less often than average with this medicine.

202Reports
30%Marked serious
30%Recovered
12%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
34 37%
1–2 days
12 13%
3–7 days
3 3.3%
1–4 weeks
13 14%
Over a month
30 33%

How the animals did

Recovered
45 22%
Recovered with lasting effects
16 7.9%
Still unwell when reported
20 9.9%
Died
16 7.9%
Euthanised
9 4.5%
Not known
96 48%

Problems reported at the same time

Age of the animals

Under 1 year
14
1–3 years
63
4–7 years
60
8–11 years
35
12+ years
24

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause pain in dogs?
202 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pain with similar medicines

All reported side effects of Spinosad in dogs · Medicines most reported with pain