Nausea after Spinosad (Comfortis) in dogs

240 reports to the FDA describe nausea in dogs given Spinosad. That is 0.4% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

240Reports

21%Marked serious

48%Recovered

5.0%Died or euthanised

Same dayTypical onset

How soon it started

Same day

78 56%

1–2 days

9 6.5%

3–7 days

2 1.4%

1–4 weeks

4 2.9%

Over a month

46 33%

How the animals did

Recovered

96 40%

Recovered with lasting effects

19 7.9%

Still unwell when reported

20 8.3%

Died

7 2.9%

Euthanised

5 2.1%

Not known

93 39%

Problems reported at the same time

129 54%

102 43%

55 23%

47 20%

29 12%

27 11%

23 9.6%

17 7.1%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Spinosad kills fleas; monthly chewable.

Products with this ingredient include Comfortis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Spinosad cause nausea in dogs?: 240 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Nausea with similar medicines

Nausea after Lufenuron + Milbemycin Oxime (Sentinel) 81 reports · 0.3% of its reports
Nausea after Nitenpyram (Capstar) 21 reports · 0.2% of its reports
Nausea after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 31 reports · 0.3% of its reports

All reported side effects of Spinosad in dogs · Medicines most reported with nausea