Stumbling gait after Sarolaner (Simparica) in dogs

The FDA has received 99 reports of stumbling gait in dogs after Sarolaner. That is 0.6% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

99Reports
46%Marked serious
24%Recovered
5.1%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
46 49%
1–2 days
12 13%
3–7 days
9 9.6%
1–4 weeks
8 8.5%
Over a month
19 20%

How the animals did

Recovered
24 24%
Still unwell when reported
49 49%
Died
1 1.0%
Euthanised
4 4.0%
Not known
21 21%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
9
4–7 years
15
8–11 years
26
12+ years
41

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause stumbling gait in dogs?
99 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Stumbling gait with similar medicines

All reported side effects of Sarolaner in dogs · Medicines most reported with stumbling gait