Neutrophilia after Sarolaner (Simparica) in dogs

81 reports to the FDA describe neutrophilia in dogs given Sarolaner. That is 0.5% of all reports for this medicine, compared with 0.6% across reports for all dog medicines.

81Reports

73%Marked serious

12%Recovered

21%Died or euthanised

1 daysTypical onset

How soon it started

Same day

28 39%

1–2 days

14 19%

3–7 days

8 11%

1–4 weeks

11 15%

Over a month

11 15%

How the animals did

Recovered

9 11%

Recovered with lasting effects

1 1.2%

Still unwell when reported

48 59%

Died

5 6.2%

Euthanised

12 15%

Not known

6 7.4%

Problems reported at the same time

51 63%

43 53%

36 44%

35 43%

35 43%

24 30%

22 27%

20 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause neutrophilia in dogs?: 81 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutrophilia with similar medicines

Neutrophilia after Fluralaner (Bravecto) 452 reports · 0.7% of its reports
Neutrophilia after Afoxolaner (NexGard) 356 reports · 0.6% of its reports
Neutrophilia after Lotilaner (Credelio) 66 reports · 0.7% of its reports
Neutrophilia after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 54 reports · 0.6% of its reports
Neutrophilia after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 24 reports · 0.8% of its reports

All reported side effects of Sarolaner in dogs · Medicines most reported with neutrophilia