Adipsia after Sarolaner (Simparica) in dogs

The FDA has received 78 reports of adipsia in dogs after Sarolaner. That is 0.5% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

78Reports
49%Marked serious
18%Recovered
6.4%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
42 55%
1–2 days
23 30%
3–7 days
7 9.1%
1–4 weeks
2 2.6%
Over a month
3 3.9%

How the animals did

Recovered
14 18%
Still unwell when reported
34 44%
Died
2 2.6%
Euthanised
3 3.8%
Not known
25 32%

Problems reported at the same time

Age of the animals

Under 1 year
11
1–3 years
18
4–7 years
17
8–11 years
21
12+ years
10

About this medicine

Sarolaner kills fleas, ticks and some mites; monthly.

Products with this ingredient include Simparica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Sarolaner cause adipsia in dogs?
78 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Adipsia with similar medicines

All reported side effects of Sarolaner in dogs · Medicines most reported with adipsia