Hypoproteinaemia after Pyrantel in dogs

The FDA has received 22 reports of hypoproteinaemia in dogs after Pyrantel. That is 0.5% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

22Reports

59%Marked serious

23%Recovered

36%Died or euthanised

10 daysTypical onset

How soon it started

Same day

2 13%

1–2 days

2 13%

3–7 days

3 20%

1–4 weeks

4 27%

Over a month

4 27%

How the animals did

Recovered

5 23%

Still unwell when reported

5 23%

Died

5 23%

Euthanised

3 14%

Not known

4 18%

Problems reported at the same time

15 68%

13 59%

9 41%

9 41%

8 36%

8 36%

8 36%

7 32%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Pyrantel treats roundworms and hookworms.

Questions owners ask

Can Pyrantel cause hypoproteinaemia in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 10 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoproteinaemia with similar medicines

Hypoproteinaemia after Pyrantel + Sarolaner (Simparica Trio) 38 reports · 0.1% of its reports
Hypoproteinaemia after Fenbendazole 32 reports · 0.5% of its reports

All reported side effects of Pyrantel in dogs · Medicines most reported with hypoproteinaemia