Injection site reaction after Penicillin in dogs

The FDA has received 21 reports of injection site reaction in dogs after Penicillin. That is 8.3% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

21Reports

67%Marked serious

52%Recovered

4.8%Died or euthanised

3 daysTypical onset

How soon it started

Same day

5 24%

1–2 days

4 19%

3–7 days

7 33%

1–4 weeks

4 19%

Over a month

1 4.8%

How the animals did

Recovered

11 52%

Still unwell when reported

9 43%

Died

1 4.8%

Problems reported at the same time

5 24%

4 19%

3 14%

3 14%

Dermal thickening

2 9.5%

Hair loss

2 9.5%

Skin slough

2 9.5%

Vocalising

2 9.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Penicillin cause injection site reaction in dogs?: 21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

Injection site reaction after Melarsomine (Immiticide) 3,290 reports · 15% of its reports
Injection site reaction after Polysulfated Glycosaminoglycan 263 reports · 4.8% of its reports
Injection site reaction after Diphenhydramine 398 reports · 8.4% of its reports
Injection site reaction after Butorphanol 479 reports · 11% of its reports
Injection site reaction after Cefpodoxime 81 reports · 2.0% of its reports
Injection site reaction after Tramadol 123 reports · 3.3% of its reports
Injection site reaction after Desoxycorticosterone Pivalate 165 reports · 4.9% of its reports
Injection site reaction after Propofol 170 reports · 5.5% of its reports
Injection site reaction after Isoflurane 126 reports · 4.6% of its reports
Injection site reaction after Cephalexin 31 reports · 1.2% of its reports

All reported side effects of Penicillin in dogs · Medicines most reported with injection site reaction