Dilated pupils after Oclacitinib (Apoquel) in dogs

The FDA has received 41 reports of dilated pupils in dogs after Oclacitinib. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.

41Reports

59%Marked serious

15%Recovered

17%Died or euthanised

1 daysTypical onset

How soon it started

Same day

14 42%

1–2 days

7 21%

3–7 days

2 6.1%

1–4 weeks

3 9.1%

Over a month

7 21%

How the animals did

Recovered

6 15%

Still unwell when reported

22 54%

Died

4 9.8%

Euthanised

3 7.3%

Not known

6 15%

Problems reported at the same time

15 37%

10 24%

9 22%

9 22%

Eye or vision problems

8 20%

Loss of appetite

7 17%

Death

7 17%

Behaviour change

7 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause dilated pupils in dogs?: 41 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Oclacitinib in dogs · Medicines most reported with dilated pupils