Dermal nodule after Oclacitinib (Apoquel) in dogs

26 reports to the FDA describe dermal nodule in dogs given Oclacitinib. That is 0.1% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports

50%Marked serious

15%Recovered

19%Died or euthanised

151 daysTypical onset

How soon it started

Same day

2 13%

1–2 days

1 6.7%

3–7 days

0 0.0%

1–4 weeks

1 6.7%

Over a month

11 73%

How the animals did

Recovered

4 15%

Still unwell when reported

15 58%

Died

1 3.8%

Euthanised

4 15%

Not known

2 7.7%

Problems reported at the same time

5 19%

5 19%

4 15%

4 15%

4 15%

Abnormal radiograph finding

4 15%

Dermal cyst(s)

4 15%

Abnormal cytology

3 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause dermal nodule in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 151 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Oclacitinib in dogs · Medicines most reported with dermal nodule