Decreased red blood cell count after Oclacitinib (Apoquel) in dogs

The FDA has received 106 reports of decreased red blood cell count in dogs after Oclacitinib. That is 0.4% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

106Reports
49%Marked serious
6.6%Recovered
22%Died or euthanised
71 daysTypical onset
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How soon it started

Same day
7 10%
1–2 days
3 4.3%
3–7 days
0 0.0%
1–4 weeks
9 13%
Over a month
50 72%

How the animals did

Recovered
7 6.6%
Still unwell when reported
55 52%
Died
6 5.7%
Euthanised
17 16%
Not known
21 20%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
12
4–7 years
36
8–11 years
38
12+ years
20

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause decreased red blood cell count in dogs?
106 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 71 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Decreased red blood cell count with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with decreased red blood cell count