Urine abnormalities after Moxidectin (ProHeart 6) in dogs

59 reports to the FDA describe urine abnormalities in dogs given Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

59Reports

56%Marked serious

8.5%Recovered

22%Died or euthanised

3 daysTypical onset

How soon it started

Same day

13 25%

1–2 days

10 19%

3–7 days

13 25%

1–4 weeks

4 7.7%

Over a month

12 23%

How the animals did

Recovered

5 8.5%

Still unwell when reported

39 66%

Died

2 3.4%

Euthanised

11 19%

Not known

2 3.4%

Problems reported at the same time

31 53%

29 49%

24 41%

19 32%

18 31%

16 27%

13 22%

13 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause urine abnormalities in dogs?: 59 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urine abnormalities with similar medicines

Urine abnormalities after Ivermectin + Pyrantel (Heartgard Plus) 74 reports · 0.1% of its reports
Urine abnormalities after Milbemycin Oxime + Spinosad (Trifexis) 210 reports · 0.2% of its reports
Urine abnormalities after Milbemycin Oxime + Praziquantel (Interceptor Plus) 58 reports · 0.2% of its reports
Urine abnormalities after Milbemycin Oxime (Interceptor) 20 reports · 0.1% of its reports
Urine abnormalities after Ivermectin (Heartgard) 27 reports · 0.2% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with urine abnormalities