Pancreatitis after Moxidectin (ProHeart 6) in dogs

139 reports to the FDA describe pancreatitis in dogs given Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

139Reports

56%Marked serious

8.6%Recovered

24%Died or euthanised

1 daysTypical onset

How soon it started

Same day

24 26%

1–2 days

33 36%

3–7 days

16 17%

1–4 weeks

11 12%

Over a month

8 8.7%

How the animals did

Recovered

12 8.6%

Still unwell when reported

59 42%

Died

17 12%

Euthanised

16 12%

Not known

35 25%

Problems reported at the same time

80 58%

60 43%

57 41%

51 37%

43 31%

33 24%

23 17%

High pancreatic-specific lipase

22 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause pancreatitis in dogs?: 139 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pancreatitis with similar medicines

Pancreatitis after Ivermectin + Pyrantel (Heartgard Plus) 192 reports · 0.1% of its reports
Pancreatitis after Milbemycin Oxime + Spinosad (Trifexis) 358 reports · 0.3% of its reports
Pancreatitis after Milbemycin Oxime + Praziquantel (Interceptor Plus) 74 reports · 0.2% of its reports
Pancreatitis after Milbemycin Oxime (Interceptor) 59 reports · 0.2% of its reports
Pancreatitis after Selamectin (Revolution) 43 reports · 0.1% of its reports
Pancreatitis after Ivermectin (Heartgard) 35 reports · 0.3% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with pancreatitis