Pancreatitis after Milbemycin Oxime (Interceptor) in dogs

59 reports to the FDA describe pancreatitis in dogs given Milbemycin Oxime. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

59Reports

46%Marked serious

12%Recovered

25%Died or euthanised

11 daysTypical onset

How soon it started

Same day

2 15%

1–2 days

3 23%

3–7 days

1 7.7%

1–4 weeks

2 15%

Over a month

5 38%

How the animals did

Recovered

6 10%

Recovered with lasting effects

1 1.7%

Still unwell when reported

13 22%

Died

9 15%

Euthanised

6 10%

Not known

24 41%

Problems reported at the same time

34 58%

22 37%

19 32%

16 27%

16 27%

15 25%

14 24%

11 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause pancreatitis in dogs?: 59 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 11 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Pancreatitis with similar medicines

Pancreatitis after Ivermectin + Pyrantel (Heartgard Plus) 192 reports · 0.1% of its reports
Pancreatitis after Milbemycin Oxime + Spinosad (Trifexis) 358 reports · 0.3% of its reports
Pancreatitis after Moxidectin (ProHeart 6) 139 reports · 0.3% of its reports
Pancreatitis after Milbemycin Oxime + Praziquantel (Interceptor Plus) 74 reports · 0.2% of its reports
Pancreatitis after Selamectin (Revolution) 43 reports · 0.1% of its reports
Pancreatitis after Ivermectin (Heartgard) 35 reports · 0.3% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with pancreatitis