Elevated amylase after Milbemycin Oxime (Interceptor) in dogs

33 reports to the FDA describe elevated amylase in dogs given Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

33Reports
18%Marked serious
0.0%Recovered
39%Died or euthanised
–Typical onset
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How the animals did

Still unwell when reported
2 6.1%
Died
10 30%
Euthanised
3 9.1%
Not known
18 55%

Problems reported at the same time

Vomiting
17 52%
Liver problems
15 45%
Elevated lipase
15 45%
Death
14 42%
Lethargy
12 36%
Loss of appetite
11 33%
Pancreatitis
11 33%
Kidney problems
8 24%

Age of the animals

Under 1 year
2
1–3 years
9
4–7 years
9
8–11 years
10
12+ years
3

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause elevated amylase in dogs?
33 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated amylase with similar medicines

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with elevated amylase