Ocular discharge after Moxidectin (ProHeart 6) in dogs

68 reports to the FDA describe ocular discharge in dogs given Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.

68Reports

50%Marked serious

12%Recovered

21%Died or euthanised

4 daysTypical onset

How soon it started

Same day

13 27%

1–2 days

6 13%

3–7 days

8 17%

1–4 weeks

16 33%

Over a month

5 10%

How the animals did

Recovered

8 12%

Still unwell when reported

29 43%

Died

6 8.8%

Euthanised

8 12%

Not known

17 25%

Problems reported at the same time

39 57%

32 47%

18 26%

17 25%

16 24%

14 21%

14 21%

12 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause ocular discharge in dogs?: 68 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Ocular discharge with similar medicines

Ocular discharge after Ivermectin + Pyrantel (Heartgard Plus) 111 reports · 0.1% of its reports
Ocular discharge after Milbemycin Oxime + Spinosad (Trifexis) 142 reports · 0.1% of its reports
Ocular discharge after Milbemycin Oxime + Praziquantel (Interceptor Plus) 47 reports · 0.1% of its reports
Ocular discharge after Milbemycin Oxime (Interceptor) 21 reports · 0.1% of its reports
Ocular discharge after Selamectin (Revolution) 44 reports · 0.1% of its reports
Ocular discharge after Ivermectin (Heartgard) 31 reports · 0.3% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with ocular discharge