Ocular discharge after Milbemycin Oxime (Interceptor) in dogs

The FDA has received 21 reports of ocular discharge in dogs after Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

21Reports

38%Marked serious

9.5%Recovered

9.5%Died or euthanised

–Typical onset

How the animals did

Recovered

1 4.8%

Recovered with lasting effects

1 4.8%

Still unwell when reported

4 19%

Died

1 4.8%

Euthanised

1 4.8%

Not known

13 62%

Problems reported at the same time

9 43%

7 33%

6 29%

5 24%

5 24%

4 19%

Eye disorder (for photophobia see 'neurological')

3 14%

Didn't stop worms

3 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause ocular discharge in dogs?: 21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Ocular discharge with similar medicines

Ocular discharge after Ivermectin + Pyrantel (Heartgard Plus) 111 reports · 0.1% of its reports
Ocular discharge after Milbemycin Oxime + Spinosad (Trifexis) 142 reports · 0.1% of its reports
Ocular discharge after Moxidectin (ProHeart 6) 68 reports · 0.1% of its reports
Ocular discharge after Milbemycin Oxime + Praziquantel (Interceptor Plus) 47 reports · 0.1% of its reports
Ocular discharge after Selamectin (Revolution) 44 reports · 0.1% of its reports
Ocular discharge after Ivermectin (Heartgard) 31 reports · 0.3% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with ocular discharge