Eye disorder (for photophobia see 'neurological') after Milbemycin Oxime (Interceptor) in dogs

33 reports to the FDA describe eye disorder (for photophobia see 'neurological') in dogs given Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

33Reports
42%Marked serious
15%Recovered
0.0%Died or euthanised
–Typical onset
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How the animals did

Recovered
3 9.1%
Recovered with lasting effects
2 6.1%
Still unwell when reported
6 18%
Not known
22 67%

Problems reported at the same time

Lethargy
10 30%
Tremors
6 18%
Eye or vision problems
6 18%
Loss of appetite
5 15%
Seizures
5 15%
Liver problems
4 12%
Wobbliness (ataxia)
4 12%
Restlessness or agitation
3 9.1%

Age of the animals

Under 1 year
0
1–3 years
10
4–7 years
11
8–11 years
8
12+ years
1

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause eye disorder (for photophobia see 'neurological') in dogs?
33 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eye disorder (for photophobia see 'neurological') with similar medicines

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with eye disorder (for photophobia see 'neurological')