Eye disorder (for photophobia see 'neurological') after Moxidectin (ProHeart 6) in dogs

70 reports to the FDA describe eye disorder (for photophobia see 'neurological') in dogs given Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

70Reports
37%Marked serious
16%Recovered
5.7%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
24 45%
1–2 days
8 15%
3–7 days
8 15%
1–4 weeks
6 11%
Over a month
7 13%

How the animals did

Recovered
11 16%
Still unwell when reported
37 53%
Died
2 2.9%
Euthanised
2 2.9%
Not known
18 26%

Problems reported at the same time

Age of the animals

Under 1 year
2
1–3 years
20
4–7 years
21
8–11 years
17
12+ years
9

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause eye disorder (for photophobia see 'neurological') in dogs?
70 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Eye disorder (for photophobia see 'neurological') with similar medicines

All reported side effects of Moxidectin in dogs · Medicines most reported with eye disorder (for photophobia see 'neurological')