Muscle wasting after Moxidectin (ProHeart 6) in dogs
The FDA has received 37 reports of muscle wasting in dogs after Moxidectin. That is 0.1% of all reports for this medicine, compared with 0.1% across reports for all dog medicines.
37Reports
30%Marked serious
0.0%Recovered
24%Died or euthanised
–Typical onset
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How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).
Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Moxidectin cause muscle wasting in dogs?
- 37 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Muscle wasting with similar medicines
- Muscle wasting after Ivermectin + Pyrantel (Heartgard Plus) 25 reports · 0.0% of its reports
- Muscle wasting after Milbemycin Oxime + Spinosad (Trifexis) 66 reports · 0.1% of its reports
All reported side effects of Moxidectin in dogs · Medicines most reported with muscle wasting