Hypoproteinaemia after Moxidectin (ProHeart 6) in dogs

186 reports to the FDA describe hypoproteinaemia in dogs given Moxidectin. That is 0.4% of all reports for this medicine, compared with 0.3% across reports for all dog medicines.

186Reports

48%Marked serious

7.0%Recovered

39%Died or euthanised

Same dayTypical onset

How soon it started

Same day

56 54%

1–2 days

14 14%

3–7 days

10 9.7%

1–4 weeks

10 9.7%

Over a month

13 13%

How the animals did

Recovered

13 7.0%

Still unwell when reported

55 30%

Died

47 25%

Euthanised

26 14%

Not known

45 24%

Problems reported at the same time

113 61%

109 59%

96 52%

95 51%

79 42%

79 42%

74 40%

73 39%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause hypoproteinaemia in dogs?: 186 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hypoproteinaemia with similar medicines

Hypoproteinaemia after Ivermectin + Pyrantel (Heartgard Plus) 114 reports · 0.1% of its reports
Hypoproteinaemia after Milbemycin Oxime + Spinosad (Trifexis) 168 reports · 0.1% of its reports
Hypoproteinaemia after Milbemycin Oxime + Praziquantel (Interceptor Plus) 42 reports · 0.1% of its reports
Hypoproteinaemia after Milbemycin Oxime (Interceptor) 51 reports · 0.2% of its reports
Hypoproteinaemia after Selamectin (Revolution) 52 reports · 0.2% of its reports
Hypoproteinaemia after Ivermectin (Heartgard) 25 reports · 0.2% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with hypoproteinaemia